txid766764[Organism:exp] AND (pcassay_pccompound_activityconcnanomolar - PubChem BioAssay - NCBI

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Select item 7498471.

Inhibition of wild type Candida albicans MY1055 1,3-beta-D-glucan synthase using UDP[6,3H]-glucose as substrate after 60 mins by liquid scintillation counting analysis

Source:: ChEMBL

Protein Target:: 1,3-beta-D-glucan synthase catalytic subunit

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 749847

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17994802.

Inhibition Assay from Article 10.1016/S1074-5521(02)00240-5: "Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors."

Source:: BindingDB

Protein Targets:: Glycylpeptide N-tetradecanoyltransferase; ...
Total:: 2

Assay data:6 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested

AID:: 1799480

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17176483.

Inhibition of Candida albicans chitin synthase 1 expressed in Saccharomyces cerevisiae RRA400-1U cells using [3H]UDP-GlcNAc as substrate by scintillation counting method

Source:: ChEMBL

Protein Target:: Chitin synthase 1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1717648

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15433014.

Antimicrobial activity against Candida albicans ATCC 90028 assessed as inhibition of microbial growth by CLSI based method

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1543301

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 13800505.

Inhibition of Candida albicans ATCC 90028 NMT using GLTISKLFRR-NH2 as substrate assessed as reduction in [3H]-myristoylated peptide reaction product formation preincubated with substrate for 10 mins followed by enzyme addition measured after 10 mins by HPLC analysis

Source:: ChEMBL

Protein Target:: Glycylpeptide N-tetradecanoyltransferase

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1380050

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 13370606.

Antifungal activity against Candida albicans HLY4123 after 16 hrs in presence of 0.25 ug/ml of fluconazole by ten fold serial dilution method

Source:: ChEMBL

Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 14 Tested

AID:: 1337060

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 12608217.

Competitive inhibition of Candida albicans DHFR preincubated for 2 mins followed by substrate addition in presence of dihydrofolate

Source:: ChEMBL

Protein Target:: Dihydrofolate reductase

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1260821

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 12361838.

Inhibition of candida albicans beta-(1,3)-glucan synthase assessed as decrease in transfer of radiolabelled glucose from UDP-[3H]-glucose onto acceptor

Source:: ChEMBL

Assay data:4 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1236183

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 12339199.

Time dependent inhibition of Candida albicans ATCC 38247 membrane inositol phosphorylceramide synthase using ceramide as substrate

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1233919

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 109445510.

Inhibition of candida N-myristoyltransferase

Source:: ChEMBL

Protein Target:: Glycylpeptide N-tetradecanoyltransferase

Assay data:25 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 28 Tested

AID:: 1094455

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 54241011.

Inhibition of Candida albicans inositol phosphorylceramide synthase

Source:: ChEMBL

Protein Target:: Inositol phosphorylceramide synthase

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 542410

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 54240512.

Inhibition of Candida albicans ATCC 38247 inositol phosphorylceramide synthase preincubated for 30 mins

Source:: ChEMBL

Protein Target:: Inositol phosphorylceramide synthase

Assay data:4 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 6 Tested

AID:: 542405

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 31106113.

Inhibition of Candida albicans OSC

Source:: ChEMBL

Protein Target:: Lanosterol synthase

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 311061

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 31093714.

Inhibition of Candida albicans N-myristoyltransferse

Source:: ChEMBL

Protein Target:: Glycylpeptide N-tetradecanoyltransferase

Assay data:33 Active, 2 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 47 Tested

AID:: 310937

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15164115.

Compound was tested for inhibition of purified Oxidosqualene-lanosterol cyclase from Candida albicans

Source:: ChEMBL

Protein Target:: Lanosterol synthase

Assay data:4 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 4 Tested

AID:: 151641

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14393216.

In vitro inhibitory activity against candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)

Source:: ChEMBL

Protein Targets:: Glycylpeptide N-tetradecanoyltransferase 1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 143932

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14393017.

In vitro inhibitory activity against Candida albicans Nmt (CaNmt) using substrate peptide GLTISKLFR-R-NH2 (0.5 uM) and myristoyl-CoA (0.5 uM)

Source:: ChEMBL

Protein Targets:: Glycylpeptide N-tetradecanoyltransferase 1; ...
Total:: 2

Assay data:9 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested

AID:: 143930

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5810018.

Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Mycobacterium lufu

Source:: ChEMBL

Protein Target:: Dihydrofolate reductase

Assay data:35 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 43 Tested

AID:: 58100

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5710719.

Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Escherichia coli

Source:: ChEMBL

Protein Target:: Dihydrofolate reductase

Assay data:40 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 43 Tested

AID:: 57107

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 5707620.

Inhibition of Dihydrofolate reductase enzyme from Candida albicans

Source:: ChEMBL

Protein Target:: Dihydrofolate reductase

Assay data:23 Active, 17 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested

AID:: 57076

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Active Compounds (30)
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Activity (IC50, etc) ≤ 1 nM (30)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (30)
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